The largest database of trusted experimental protocols

Polyplasdone™ XL

Manufactured by Ashland
Sourced in Switzerland, France

Polyplasdone™ XL is a polyvinylpyrrolidone (PVP) polymer product designed for use as an excipient in pharmaceutical and nutraceutical formulations. It acts as a binder, disintegrant, and solubilizing agent. The core function of Polyplasdone™ XL is to improve the physical and chemical properties of drug products.

Automatically generated - may contain errors

4 protocols using Polyplasdone™ XL

1

Formulation and Quality Control of Curcumin-Boswellia Extract

For the clinical study, the sunflower lecithin-based formulation of C. longa L. and B. serrata standardized extracts (500 mg) was prepared by Indena S.p.A., as oblong-shaped, film-coated tablets, corresponding to a content of 17.0–23.0% w/w of curcumin and 7.0–11.0% w/w of boswellia extracts, respectively by high performance liquid chromatography (HPLC) assay. The active ingredient is a solid dispersion containing the standardized association of curcumin extract (≥90% as total curcuminoids assessed by HPLC assay) and boswellia extract (≥65.0% of total triterpenic acids assessed by HPLC assay). The remaining food-grade components of the phytosome tablets are calcium carbonate E170 (95DC M; Dr Paul Lohman®), polyvinylpolypyrrolidone E1202 (Polyplasdone XL; Ashland), sodium croscarmellose E468 (Solutab® A-IP; Blanver Farmoquimica LTDA), silicon dioxide E551 (Syloid® 244FP; Grace), talc E553b (Mondo Minerals B.V.), magnesium stearate E470b (Ligafood®; Peter Greven Nederland C.V.), and hydroxypropyl methylcellulose E463-based film-coating (Opadry® Clear; Colorcon). Before releasing, the film-coated tablets containing the food-grade lecithin formulation were tested for appearance, average mass, uniformity of mass, HPLC-content of curcumin and boswellia extracts, disintegration time, and microbiological quality.
+ Open protocol
+ Expand
Choline alfoscerate was purchased from HanseoChem (Pyeongtaek, Republic of Korea). Neusilin® (magnesium aluminometasilicate; Fuji Chemical, Osaka, Japan) was used to control the water absorption of drug and to improve the granule fluidity. Polyvinylpyrrolidone (PVP) K-30 (BASF, Ludwigshafen, Germany) was added as a binder. Micro-crystalline cellulose (Mingtai Chemical, Mountainside, Bah-Der, Taiwan), lactose monohydrate and lactose anhydrous (DFE Pharma, Goch, Germany), and dicalcium phosphate anhydrous (A-TAB; Innophos, Cranbury, NJ, USA) were used as excipients for the tablets. Croscarmel-lose sodium (DFE Pharma), sodium starch glycolate (Yung Zip, Taichung, Taiwan), crospovidone (Polyplasdone XL; Ashland, Covington, KY, USA), magnesium stearate (FACI, Carasco, Italy), and sodium stearyl fumarate (Pruv; JRS Pharma, Rosenberg, Germany) were used as superdisin-tegrant and lubricant, respectively. Opadry I® and Opadry AMB® were obtained from Colorcon (Shanghai, China). Gliatilin® soft capsules (Daewoong Pharmaceutical, Seoul, Republic of Korea) were purchased from a local pharmacy.
+ Open protocol
+ Expand
3

Characterization of Pharmaceutical Polymer Formulations

In this study, two pharmaceutical polymers, which are commonly used as carriers for the manufacturing of ASDs, vinylpyrrolidone vinylacetate copolymer (Kollidon VA64, BASF, Basel, Switzerland) and aminoalkyl methacrylate copolymer (Eudragit EPO, Evonik, Essen, Germany) were investigated in a formulation with fillers and disintegrants. Microcrystalline cellulose (MCC, Vivapur®102, JRS Pharma, Rosenberg, Germany), a hydrophilic and water-insoluble excipient with plastic deformation behaviour, was used as filler [39 (link)]. Cross-linked sodium carboxymethyl cellulose (NaCMCXL, AcDiSol®SD-711, FMC Europe NV, Brussels, Belgium) and polyvinyl polypyrrolidone (PVPP, Polyplasdone™ XL, Ashland, Schaffhausen, Switzerland) were employed as disintegrants. Rhodamine B (RhB, Merck, Darmstadt, Germany) was used as fluorescent dye. Aqueous dispersions of spherical polyethylene (PE) particles of four different particle size ranges (45–53 µm, 125–150 µm, 355–425 µm, 710–850 µm) containing an orange fluorescent dye (Cospheric LLC, Santa Barbara, CA, USA) were prepared with Polysorbate 80 (Tween® 80, Merck, Darmstadt, Germany) as dispersant and used to verify the analytical method. The dispersion with the finest PE particles was additionally used as calibration suspension. Demineralised water at 22 ± 2 °C with a pH of 7 was used as test medium throughout the study.
+ Open protocol
+ Expand
DAP-CA cocrystal (99.9% purity) was obtained from Sun Pharm. Industries, Ltd. (Mumbai, India). Anhydrous lactose (Supertab 21AN) was obtained from DFE Pharma (Goch, Germany). Lactose monohydrate (Tablettose) was obtained from Meggle Pharma (Wasserburg, Germany). Microcrystalline cellulose (Avicel PH-101) was purchased from FMC biopolymer (Philadelphia, PA, USA). Microcrystalline cellulose (Vivapur 12) was obtained from JRS Pharma (Rosenberg, Germany). Mannitol (Pearlitol 100 SD) was obtained from ROQUETTE Pharma (Lestrem, France), crospovidone (Polyplasdone XL) was provided by Ashland (DA, USA), colloidal silicon dioxide (Aerosil 200 pharma) was purchased from Evonik (Essen, Germany), and magnesium stearate was purchased from FACI (Genova, Italy). Opadry was purchased from Colorcon (Stoughton, WI, USA). DAP amorphous (99.9% purity) and DAP-PH (99.9% purity) were provided by Dr. Reddy (Hyderabad, India), and Forxiga® 10 mg, a control agent, was provided by AstraZeneca Korea (Seoul, Korea).
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!