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Immunoverse assay

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The Immunoverse™ assay is a comprehensive immune profiling platform developed by Adaptive Biotechnologies. The assay utilizes high-throughput DNA sequencing to analyze the adaptive immune system by identifying and quantifying T-cell and B-cell receptor sequences.

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Lab products found in correlation

Archerdx, by Adaptive Biotechnologies (2 mentions) Immunoseq, by Adaptive Biotechnologies (2 mentions)

2 protocols using immunoverse assay

1

TCR Sequencing and Clonality Quantification in Neuroinflammation

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TCR sequencing and clonality quantification was assessed in neuropathologist-selected (author BM) FFPE samples of highly inflamed and non-inflamed brain parenchyma using survey level immunoSEQ™ and the Immunoverse™ assay, as previously described (Adaptive Biotechnologies, ArcherDX)39 ,40 . Sequencing results were evaluated using the immunoSEQ analyzer version 3.0. Shannon entropy, a measure of sample diversity, was calculated on the clonal abundance of all productive TCR sequences in the data set. Shannon entropy was normalized by dividing Shannon entropy by the logarithm of the number of unique productive TCR sequences. This normalized entropy value was then inverted (1 − normalized entropy) to produce the clonality metric.
Johnson D.B., McDonnell W.J., Ericsson-Gonzalez P.I., Al-Rohil R., Mobley B.C., Salem J.E., Wang D.Y., Sanchez V., Wang Y., Chastain C.A., Barker K., Liang Y., Warren S., Beechem J., Menzies A.M., Tio M., Long G.V., Cohen J.V., Guidon A.C., O’Hare M., Chandra S., Chowdhary A., Lebrun-Vignes B., Goldinger S., Rushing E., Buchbinder E., Mallal S.A., Shi C., Xu Y., Moslehi J.J., Sanders M.E., Sosman J.A, & Balko J.M. (2019). A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis. Nature medicine, 25(8), 1243-1250.
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2

TCR Sequencing and Clonality Quantification in Neuroinflammation

Check if the same lab product or an alternative is used in the 5 most similar protocols
TCR sequencing and clonality quantification was assessed in neuropathologist-selected (author BM) FFPE samples of highly inflamed and non-inflamed brain parenchyma using survey level immunoSEQ™ and the Immunoverse™ assay, as previously described (Adaptive Biotechnologies, ArcherDX)39 ,40 . Sequencing results were evaluated using the immunoSEQ analyzer version 3.0. Shannon entropy, a measure of sample diversity, was calculated on the clonal abundance of all productive TCR sequences in the data set. Shannon entropy was normalized by dividing Shannon entropy by the logarithm of the number of unique productive TCR sequences. This normalized entropy value was then inverted (1 − normalized entropy) to produce the clonality metric.
Johnson D.B., McDonnell W.J., Ericsson-Gonzalez P.I., Al-Rohil R., Mobley B.C., Salem J.E., Wang D.Y., Sanchez V., Wang Y., Chastain C.A., Barker K., Liang Y., Warren S., Beechem J., Menzies A.M., Tio M., Long G.V., Cohen J.V., Guidon A.C., O’Hare M., Chandra S., Chowdhary A., Lebrun-Vignes B., Goldinger S., Rushing E., Buchbinder E., Mallal S.A., Shi C., Xu Y., Moslehi J.J., Sanders M.E., Sosman J.A, & Balko J.M. (2019). A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis. Nature medicine, 25(8), 1243-1250.
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