Kollidon va 64

Q: What specific citation details should I use when referencing Kollidon VA 64 in scientific publications?

When citing Kollidon VA 64, include the following key identifiers: BASF product name 'Kollidon VA 64', CAS number 25086-89-9, chemical nomenclature 'Vinyl Pyrrolidone/Vinyl Acetate Copolymer', and the specific lot or batch number from your product documentation. Recommended citation format includes manufacturer details and precise chemical classification.

Manufactured by BASF

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Sourced in Germany, United States, United Kingdom, China, Ireland, Japan, India

About the product

Kollidon® VA 64 is a polyvinylpyrrolidone-vinyl acetate copolymer that functions as a binder, disintegrant, and solubilizer in pharmaceutical formulations.

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Lab products found in correlation

96410 16 tubing, by Masterflex (20 mentions) Peristaltic pump, by Masterflex (20 mentions) Soluplus, by BASF (17 mentions) Eudragit epo, by Evonik (11 mentions) Kollidon 30, by BASF (10 mentions) Kollicoat ir, by BASF (7 mentions) Parteck mxp, by Merck Group (7 mentions) Acetonitrile, by Merck Group (6 mentions) Hplc grade acetonitrile, by Thermo Fisher Scientific (5 mentions) Kolliphor p 407, by BASF (5 mentions) Kolliphor p188, by BASF (4 mentions) Methanol, by Merck Group (4 mentions) Mannitol, by Towa Kasei (4 mentions) Fluid bed granulator, by Ohkawara Seisakujo (4 mentions) Mov 112p, by Sanyo (4 mentions) Eudragit rs po, by Evonik (3 mentions) Kollidon k30, by BASF (3 mentions) Hpmc e5, by Dow (3 mentions) Kollidon k90, by BASF (3 mentions) Sodium dodecyl sulfate (sds), by Merck Group (3 mentions)

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Market Availability & Pricing

Kollidon® VA 64 is a commercialized product by BASF and available through authorized distributors. It is a white or slightly yellowish, free-flowing powder with a faint characteristic odor and practically no taste. The product is manufactured in Germany and available in various package sizes.

A special grade of the product, Kollidon® VA 64 NT, is scheduled to be available for order starting July 1, 2025.

Pricing information for Kollidon® VA 64 can be obtained upon request from BASF or authorized distributors.

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Spelling variants (same manufacturer)

VA 64 - 12 citations PVPVA (Kollidon® VA 64) - 3 citations Kollidon VA 64 (KVA64) - 2 citations Kollidon VA 64 (vinylpyrrolidone-vinyl acetate copolymer) - 2 citations

The spelling variants listed below correspond to different ways the product may be referred to in scientific literature.
These variants have been automatically detected by our extraction engine, which groups similar formulations based on semantic similarity.

Product FAQ

How does Kollidon VA 64 differ from other pharmaceutical excipients in the market?

Kollidon VA 64 is a unique vinyl pyrrolidone/vinyl acetate copolymer by BASF, distinguished by its excellent film-forming properties and versatility in pharmaceutical applications. Unlike alternative excipients, it offers superior binding, disintegration, and dissolution characteristics. Comparable products include Soluplus by BASF, Eudragit EPO by Evonik, and Kollidon 30, but Kollidon VA 64 provides unique performance in tablet formulations and controlled-release systems.

What specific citation details should I use when referencing Kollidon VA 64 in scientific publications?

In what pharmaceutical and research applications is Kollidon VA 64 compatible?

Kollidon VA 64 demonstrates broad compatibility with various pharmaceutical processing technologies, including tablet compression, hot-melt extrusion, spray drying, and film coating. It integrates well with equipment like fluid bed granulators, peristaltic pumps, and standard pharmaceutical manufacturing systems. Compatible complementary products include Kolliphor P407, Kollidon K30, and HPMC E5 excipients.

What primary research and pharmaceutical domains utilize Kollidon VA 64?

Kollidon VA 64 is extensively used in pharmaceutical research including oral solid dosage form development, controlled-release formulations, solubility enhancement, immediate-release tablet manufacturing, and complex drug delivery systems. Primary application domains include pharmaceutical technology, biopharmaceutical research, analytical chemistry, and advanced drug formulation strategies.

What interesting scientific innovation is associated with Kollidon VA 64?

An intriguing aspect of Kollidon VA 64 is its unique molecular structure that allows simultaneous polymer dissolution and film formation, enabling novel drug delivery mechanisms. Researchers have discovered its potential in creating advanced nanomedicine formulations and improving bioavailability of challenging pharmaceutical compounds through innovative polymer interaction mechanisms.

174 protocols using «kollidon va 64»

Formulation Development and Analysis

2025

Carvedilol, nifedipine, potassium phosphate
monobasic (KH₂PO₄), potassium phosphate dibasic
(K₂HPO₄), mucin from porcine stomach (Type III),
ammonium dihydrogen phosphate (NH₄H₂PO₄), dimethylformamide, acetonitrile (HPLC grade), and sodium hydroxide
pellets (NaOH) were purchased from Fisher Scientific. Ultrapure water
(18 MΩ) in-house station was obtained from Millipore Sigma.
Hydroxypropyl methylcellulose (Benecel E4M PHARM, HPMC) was provided
by Ashland, Inc., polyvinylpyrrolidone-vinyl acetate copolymer (Kollidon
VA 64) was provided by BASF. The chemical structures of Carvedilol,
nifedipine, and polymers are shown in Figure 1. The structure of mucin is highly complex,
but a representative structure of the O-linked mucin glycopeptide
is shown in Figure 1.

Kordorwu V., Castleberry S., Lustig S, & Carrier R.L. (2025). Mucin Mimics and Impacts the Function of Polymeric Inhibitors in Stabilizing Drug Supersaturation. Molecular Pharmaceutics, 22(3), 1396-1407.

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Solubility Enhancement of Piroxicam

2025

The active ingredient used in the study was Piroxicam sourced from Medex, Rugby, UK. The polymer carrier employed was Kollidon^® VA64 (PVPVA), generously provided by BASF, Ludwigshafen, Germany. The Piroxicam was utilized in its original form as a white powder with crystal structure identified as anhydrous I (AHI), confirmed through powder X-ray diffraction (PXRD) and Raman analysis. Thermal analysis revealed Piroxicam’s experimental glass transition (Tg) at 60 °C, melting point (Tm) ranging between 198 and 202 °C, and a notable weight loss (degradation) with onset observed at 215 °C. According to the biopharmaceutics classification system (BCS), Piroxicam falls under class II, indicating poor water solubility, specifically 23 mg/mL at 22 °C [33 (link),34 (link)].

Bezerra M., Almeida J., de Castro M., Grootveld M, & Schlindwein W. (2025). Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV–Vis Monitoring of L* as a Real-Time Response. Pharmaceutics, 17(2), 151.

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Carvedilol Formulation Development and Characterization

2024

Carvedilol (99.67%) was purchased from Dacon Natural Products (Beijing, China). Kollidon^® VA-64 (copovidone), Soluplus^® (Poly(vinyl caprolactam-covinylacetate-ethylene glycol) graft polymer) and Kolliphor^® RH40 (PEG-40 Hydrogenated Castor Oil) were received from BASF SE (Ludwigshafen am Rhein, Germany). Capmul^® MCM EP (Glycerol Monocaprylocaprate Type I EP) was provided by Abitec Corp (Janesville, WI, USA). Transcutol^® (diethylene glycol monoethyl ether) and Labrafac^® lipophile WL 1349 (medium chain triglycerides) were received from Gattefossé (Saint-Priest, France). The same raw materials and formulation compositions as listed in Table 4 were used as previously [11 (link)].

Zupančič O., Matić J., Doğan A., Gaggero A., Khinast J, & Paudel A. (2024). Comparing Low-Dose Carvedilol Continuous Manufacturing by Solid and Liquid Feeding in Self-Emulsifying Delivery Systems via Hot Melt EXtrusion (SEDEX). Pharmaceuticals, 17(10), 1290.

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Formulation and Characterization of ETD Delivery System

2024

Materials were obtained from commercial sources. ETD was supplied from Xi’an Health Biochemical Technology Co. (Xi’an, China). Kollidon 25 (polyvinylpyrrolidone, PVP) and Kollidon VA 64 (polyvinylpyrrolidone-polyvinyl acetate copolymers, PVP/VA) were provided by BASF (Burgbernheim, Germany). Pharmacoat 606 (hypromellose) was obtained from Shin-Etsu Chemical Co. (Niigata, Japan) and Poloxamer 407 (poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)) from Sigma Aldrich (Steinheim, Germany). Urea, mannitol, and potassium dihydrogen phosphate were provided by Chempur (Piekary Sląskie, Poland), and disodium hydrogen phosphate by P.P.H. Stanlab (Lublin, Poland). Water for HPLC analysis was prepared by a Milli-Q Reagent Water System (Millipore, Billerica, MA, USA), and purified water by the reverse osmosis and deionization method (apparatus type WCR-RO10-DPS, Cobrabid-Aqua, Warszawa, Poland). Acetonitrile (J.T. Baker, Deventer, The Netherlands) was of HPLC grade, and other chemicals were of analytical grade.

Czajkowska-Kośnik A., Misztalewska-Turkowicz I., Wilczewska A.Z., Basa A, & Winnicka K. (2024). Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug. Materials, 17(16), 3923.

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Copovidone-Based Surfactant Extrusion

2024

Copovidone (Kollidon VA64, BASF) was first granulated with each of Vitamin E TPGS (D-α-Tocopherol polyethylene glycol succinate, Gattefosse) and Tween 80 (Polysorbate 80, Merck KG, Darmstadt, Germany) surfactants using a Thermomix (Vorwerk), followed by sieving with 1 mm mesh. Mixtures with surfactant loadings of 3, 5, 7 and 9 wt% were then prepared. The sieved binary mixtures were extruded using a Rondol MicroLab 10 mm Twin Screw extruder (Rondol Technology Ltd, UK) at 200 rpm screw speed. Extrusion was performed at 180 °C with a feed rate of 80 to 120 g/h. The melt temperature at the die was measured by an infrared camera (Optris PI 200, Optris GmbH, Germany) and the recorded temperature was 182.5 ± 2.0 °C. The extrudate samples were milled 3 times for 10 s each using the IKA A10 Basic Mill (IKA-Werke) and subsequently passed through a Kressner sieve with a 250 µm mesh size.

Antipas G.S., Reul R., Voges K., Kyeremateng S.O., Ntallis N.A., Karalis K.T, & Miroslaw L. (2024). System-agnostic prediction of pharmaceutical excipient miscibility via computing-as-a-service and experimental validation. Scientific Reports, 14, 15106.

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