Dimethylsulfoxide

Q: How does Bio-Rad's dimethylsulfoxide (DMSO) stand out in the research chemical market?

Bio-Rad's dimethylsulfoxide offers exceptional purity and reliability, distinguishing itself through rigorous quality control. While alternatives exist from manufacturers like Sigma-Aldrich, Merck, and Thermo Scientific, our DMSO provides consistent performance across diverse experimental applications with high-grade solvent specifications.

Q: What specific citation details should I use for Bio-Rad's dimethylsulfoxide in scientific publications?

When referencing Bio-Rad's dimethylsulfoxide, include the catalog number, lot number, and manufacturer. Typical format: 'Dimethylsulfoxide (DMSO), Bio-Rad, Catalog #XXXXX, Lot #YYYYY'. Confirm precise citation guidelines with your specific journal's formatting requirements.

Q: What laboratory systems and experimental protocols are compatible with Bio-Rad's dimethylsulfoxide?

Bio-Rad's DMSO demonstrates broad compatibility with cell culture, molecular biology, and biochemical procedures. It integrates seamlessly with complementary reagents like ascorbic acid, cell culture media, and various buffer systems, making it versatile for research applications in molecular, cellular, and biochemical domains.

Q: In what primary research domains is dimethylsulfoxide most frequently utilized?

Dimethylsulfoxide is extensively used in cell biology, cryopreservation, pharmaceutical research, organic synthesis, and biochemical studies. Key applications include solvent mediation, cell membrane permeabilization, cryoprotection, and as a specialized solvent for challenging compounds in pharmaceutical and biological research.

Q: What unique scientific insight makes dimethylsulfoxide fascinating to researchers?

Beyond its common uses, DMSO has demonstrated remarkable properties as a potential neuroprotective agent and has been investigated for its capacity to facilitate drug delivery across biological membranes, representing an intriguing intersection of chemical engineering and medical research.

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About the product

Dimethylsulfoxide is a colorless, odorless, and water-soluble liquid. It is commonly used as a solvent in various laboratory applications.

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Similar products (other manufacturers)

Dimethylsulfoxide (by Shanghai Chemical) - 4 citations Dimethylsulfoxide (DMSO) solution (by Thermo Fisher Scientific) - 4 citations Dimethylsulfoxide (by Tianjin Fuchen Chemical Reagents Factory) - 3 citations Solvent dimethylsulfoxide (DMSO; (by Merck Group) - 3 citations Dimethylsulfoxide (by Spectrochem) - 2 citations Dimethylsulfoxide (by Sintorgan) - 2 citations Dimethylsulfoxide (by Genview) - 2 citations Dimethylsulfoxide (DMSO) (by BDH Laboratory) - 2 citations Deuterated chloroform and dimethylsulfoxide (CDCl3 (by Eurisotop) - 2 citations

The spelling variants listed below correspond to different ways the product may be referred to in scientific literature.
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Product FAQ

How does Bio-Rad's dimethylsulfoxide (DMSO) stand out in the research chemical market?

What specific citation details should I use for Bio-Rad's dimethylsulfoxide in scientific publications?

What laboratory systems and experimental protocols are compatible with Bio-Rad's dimethylsulfoxide?

In what primary research domains is dimethylsulfoxide most frequently utilized?

What unique scientific insight makes dimethylsulfoxide fascinating to researchers?

5 protocols using «dimethylsulfoxide»

Synthesis of β-CD-PAMAM Conjugates

2020

All starting materials were commercially available reagent grade and were used without any further purification. β-Cyclodextrin (β-CD), PAMAM dendrimer G1 (PAMAM G1), propargyl bromide solution (80% by weight in toluene), p-toluenesulfonyl chloride (Cl-Ts), p-toluenesulfonic acid (OH-Ts), methyl 2-(4-hydroxyphenyl)acetate, N,N-dimethylformamide anhydrous (DMF), anhydrous potassium carbonate (K₂CO₃), dimethylsulfoxide (DMSO), ascorbic acid (H₂Asc), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC·HCl), Bio-Gel P-10 medium from BIO-RAD, 1-hydroxybenzotriazole hydrochloride (HOBt·HCl), N,N-diisopropylethylamina (DIPEA), potassium iodide (KI), sodium azide (NaN₃), sodium hydroxide (NaOH), copper sulfate pentahydrate (CuSO₄·5H₂O), dichloromethane (CH₂Cl₂), methanol (MeOH), ethanol (EtOH) and acetone (CH₃COCH₃) were purchased from Sigma-Aldrich.

Sorroza-Martínez K., González-Méndez I., Martínez-Serrano R.D., Solano J.D., Ruiu A., Illescas J., Zhu X.X, & Rivera E. (2020). Efficient modification of PAMAM G1 dendrimer surface with β-cyclodextrin units by CuAAC: impact on the water solubility and cytotoxicity. RSC Advances, 10(43), 25557-25566.

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Synthesis and Functionalization of Cyclotriphosphazenes

2020

All starting materials were commercially available reagent grade and were used without any further purification. Hexachlorocyclotriphosphazene (P₃N₃Cl₆), 5-chloro-1-pentyne, 6-iodo-1-hexyne, hydroquinone, β-cyclodextrin (βCD), p-toluenesulfonyl chloride (Cl-Ts), p-toluenesulfonic acid (OH-Ts), N,N-dimethylformamide anhydrous (DMF), potassium carbonate (K₂CO₃), cesium carbonate (Cs₂CO₃), dimethylsulfoxide (DMSO), ascorbic acid (H₂Asc), Bio-Gel P-10 medium from Bio-Rad (Hercules, CA, USA), potassium iodide (KI), sodium azide (NaN₃), sodium hydroxide (NaOH), copper sulfate pentahydrate (CuSO₄•5H₂O), diisopropyl ether, dichloromethane (CH₂Cl₂), ethyl acetate (EtOAc), tetrahydrofuran anhydrous (THF), hexane (HEX), methanol (MeOH), ethanol (EtOH) and acetone (CH₃COCH₃) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

Sorroza-Martínez K., González-Méndez I., Vonlanthen M., Moineau-Chane Ching K.I., Caminade A.M., Illescas J, & Rivera E. (2020). First Class of Phosphorus Dendritic Compounds Containing β-Cyclodextrin Units in the Periphery Prepared by CuAAC. Molecules, 25(18), 4034.

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Antioxidant Capacity Determination Protocol

2019

Potassium persulfate (99.5%), sodium carbonate (99%), Trolox (98%), 2,2-azinobis (3-ethylbenothiazoline-6-sulfonic acid) diammonium salt (ABTS) (98%), Folin Ciocalteu’s phenol reagent and Gallic acid (98%) were purchased from Sigma-Aldrich, South Africa. Iron (III) chloride 6-hydrate (97%), dimethyl sulfoxide (DMSO) (99.9%), Iron (II) sulfate 7-hydrate and acetic acid (87%); 2,4,6-Tri(2-pyridyl)-s-triazine (TPTZ) (99%), 2,2-diphenyl-1-picrylhydrazyl (DPPH) (96%), hydrochloric acid (35%), ascorbic acid (99%), sodium chloride (99.9%), and ethanol (99%) were purchased from BioRad, South Africa.

Aremu O.O., Oyedeji A.O., Oyedeji O.O., Nkeh-Chungag B.N, & Rusike C.R. (2019). In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats. Antioxidants, 8(8), 309.

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Colorectal and Vascular Smooth Muscle Cells Viability

2017

Cell Titer 96 MTT (3-(4,5-dimethylthiazol-z-yl)-2,5-di-phenyl tetrazolium bromide microculture tetrazolium technique) (Promega Corporation Cat.# G3580), Human Colorectal Adenocarcinoma Cell lines (HT-29) (Sigma-Aldrich) and Vascular Smooth Muscle Cells (VSMC) (PromoCell, Germany), agarose (Bio-Rad), dimethylsulfoxide (DMSO), Dulbecco's modified eagle medium (DMEM) (GibThai, Thailand), foetal bovine serum (FBS 20%) (Stem Cell Technology, Canada), penicillin (100 U/mL) and streptomycin (100 μg/mL), tween-80, sodium bicarbonate, trypsin/EDTA, propidium iodide (PI), 1 mM L-glutamine, in a 5% CO2 humidified incubator were all used.

Ofuegbe S.O., Oyagbemi A.A., Omóbòwálé T.O., Fagbohun O.S., Yakubu M.A., & Adedapo A.A. (2017). Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines. Journal of Medicinal Plants Research, 11(42), 665-672.

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Colorimetric MTT Assay for Osteoblast Proliferation

2012

The colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT; Sigma, St. Louis, MO) assay was used to assess the effect of LF on proliferation of primary osteoblasts. Therefore, cells were seeded into 96-well tissue culture plates (Corning Inc., Corning, NY) at a density of 2.5 × 10 4 cells/ cm 2 . Twenty-four hours after subculturing, cells were changed to serum-free medium for a further 12 h before the addition of LF with different iron saturation levels. Fresh media and LF samples at different concentrations (10, 100, 1,000 μg/mL) were then added for a further 44 h. After the treatment period, MTT (5 mg/mL in PBS) was added to each cell. After a 4-h incubation, the supernatant was removed and dimethylsulfoxide (Sigma) was added to solubilize MTT for 4 h. After extraction with dimethylsulfoxide, the optical density was measured at 570 nm (plate reader, Bio-Rad Laboratories, Hercules, CA).

Wang X.Y., Guo H.Y., Zhang W., Wen P.C., Zhang H., Guo Z.R, & Ren F.Z. (2013). Effect of iron saturation level of lactoferrin on osteogenic activity in vitro and in vivo. Journal of dairy science, 96(1).

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