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Pilocarpine

Manufactured by Bausch & Lomb
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Sourced in Japan, Ireland

Pilocarpine is a pharmaceutical compound used as a laboratory reagent. It functions as a muscarinic receptor agonist, primarily affecting the parasympathetic nervous system.

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Lab products found in correlation

Proparacaine, by Bausch & Lomb (2 mentions) Labview, by National Instruments (2 mentions) Tobradex, by Alcon (1 mentions) Prednisolone acetate, by Abbvie (1 mentions) Pilocarpine nitrate, by Bausch & Lomb (1 mentions) Brinzolamide, by Alcon (1 mentions)

Close spelling variants of this product

Pilocarpine nitrate

5 protocols using pilocarpine

1

Postoperative Medication Regimen After Trabeculotomy

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Postoperatively, tobramycin/dexamethasone (TobraDex, Alcon, Rijksweg, Belgium) was prescribed 4 times daily and tapered over 2 weeks, Panoprofen (PRA, Pranopulin, Sunju Pharmaceutical Co, Ltd, Japan) 4 times daily for 2 weeks, and pilocarpine 2% (Bausch & Lomb, Rochester, New York) 4 times daily for 3 months. We routinely use pilocarpine for up to 3 months to prevent the development of peripheral anterior synechiae after trabeculotomy regardless of IOP and it was not considered as an IOP lowering medication in our analysis.
Shi Y., Wang H., Oatts J., Cao K., Xin C., Liang X., Tian J., Han Y, & Wang N. (2020). Ab interno vs ab externo microcatheter‐assisted trabeculotomy for primary congenital glaucoma with clear cornea. Clinical & Experimental Ophthalmology, 48(9), 1201-1209.
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2

3D Video-oculography for Vestibulo-ocular Reflex

Cited 1 time
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To assess the efficacy of electrical stimulation we used real-time, 3-dimensional video-oculography (3D VOG) to record eye movements associated with the vestibulo-ocular reflex (VOR). This system has been previously described in detail [1 , 4 (link), 5 (link)]. The left eye was topically anesthetized via application of proparacaine (5 mg/mL; Bausch & Lomb, Rochester, NY) and the pupil constricted via pilocarpine (10 mg/mL; Bausch & Lomb, Rochester, NY) eye drops. A marker consisting of three fluorescent yellow squares on a black film was placed on the cornea using veterinary tissue glue (VetOne, Boise, ID) and illuminated via four UV-emitting diodes. A USB3 Camera (FL3-U3– 13Y3M-C, Flea3 1.3 MP Mono USB3 Vision; Point Grey, BC, Canada) retrofitted with a 1/4” format, 16.0mm-focal length, f/2.0 C-mount board lens (BL160; Allthings Inc., Australia) was used to acquire 496 400 pixel, 8-bit gray-scale images at 200 Hz using custom software written in LabVIEW (National Instruments, Austin, TX). This system captures 2-dimensional movement of the illuminated eye marker and outputs 3-dimensional eye velocities corresponding to the axes of the three semicircular canals: horizontal (H), left anterior/right posterior (LARP), and right anterior/left posterior (RALP) [6 (link)].
Aplin F.P., Singh D., Santina C.C, & Fridman G.Y. (2019). Combined ionic direct current and pulse frequency modulation improves the dynamic range of vestibular canal stimulation. Journal of vestibular research : equilibrium & orientation, 29(2-3), 89-96.
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3

Pediatric Glaucoma Surgical Protocol

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Patients will be treated with prednisolone acetate 1% (Allergan, Parsippany-Troy Hills, New Jersey, USA) six times daily in combination with topical antibiotics (tobramycin 0.3%, s.a. ALCON-COUVREUR n.v) and pilocarpine 1% (Bausch & Lomb, Rochester, New York) four times daily for the first 4 weeks after the surgery.
Postoperative follow-up visits will be performed in the paediatric glaucoma clinic at week 1, week 2, week 4, month 3 and then every 3 months (±1 weeks) for 3 years. The scheduled examinations of the follow-up visits are summarised in table 1. Chloral hydrate 10% (0.8 ml/kg, oral or rectal administration, the maximum dose is 10 mL per day) will be applied to patients not compliant for examinations.
If IOP is found to be high at a scheduled visit, topical antiglaucoma medication will be prescribed and the scheduled follow-up interval (if longer than 2 weeks) will be shortened to 2 weeks. Additional surgery will be performed if the IOP is > 21 mm Hg on maximum antiglaucoma medications (including pilocarpine 1%, brinzolamide 1% and latanoprost 0.005%) in two consecutive study visits.
Fang L., Guo X., Yang Y., Zhang J., Chen X., Zhu Y., Huang J., Huang J., Zhong Y., Xu X, & Liu X. (2020). Trabeculotomy versus combined trabeculotomy–trabeculectomy for primary congenital glaucoma: study protocol of a randomised controlled trial. BMJ Open, 10(2), e032957.
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4

Real-Time 3D Video-Oculography Technique

Cited 1 time
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To capture real-time, 3-dimensional video-oculography (3D VOG) we used a modified system described previously in detail [7 (link), 22 (link)]. The left eye was topically anesthetized, and the pupil constricted via application of proparacaine (5 mg/mL; Bausch & Lomb, Rochester, NY) and pilocarpine (10 mg/mL; Bausch & Lomb, Rochester, NY) eye drops. An array of three fluorescent yellow squares on a black film was carefully fixed to the cornea using veterinary tissue glue (VetOne, Boise, ID) and the eye illuminated in darkness via four UV-emitting diodes. A USB3 Camera (FL3-U3– 13Y3M-C, Flea3 1.3 MP Mono USB3 Vision; Point Grey, BC, Canada) retrofitted with a 1/4” format, 16.0mm-focal length, f/2.0 C-mount board lens (BL160; Allthings Inc., Australia) was used to acquire 496×400 pixel, 8-bit gray-scale images at 200 Hz using custom software written in LabVIEW (National Instruments, Austin, TX). The output of this system indicates the left eye velocity about each of three axes corresponding to the axes of the semicircular canals: horizontal (H), left anterior/right posterior (LARP), and right anterior/left posterior (RALP).
Aplin F.P., Singh D., Della Santina C.C, & Fridman G.Y. (2018). Ionic direct current modulation for combined inhibition/excitation of the vestibular system. IEEE transactions on bio-medical engineering, 66(3), 775-783.
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5

Comparative Evaluation of Ocular Hypotensive Drugs

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The ocular hypotensive drugs tested were brimonidine (0.2% brimonidine tartrate, Allergan Pharmaceuticals, Dublin, Ireland), timolol (0.5% timolol maleate, Bausch & Lomb, Tampa, FL), brinzolamide (1% brinzolamide, Alcon, Fort Worth, TX), pilocarpine (0.5% pilocarpine nitrate, Bausch & Lomb, Tampa, FL), and bimatoprost (0.03% bimatoprost, Allergan Pharmaceuticals, Dublin, Ireland).
Yu H., Zhong H., Chen J., Sun J., Huang P., Xu X., Huang S, & Zhong Y. (2020). Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 26, e925852-1-e925852-12.
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