Alphagan®, a 0.2% ophthalmic solution of brimonidine tartrate at pH 6.4 (Allergan Inc.), was topically administered. brimonidine tartrate and 5-chloro-6-(2-imidazolidinylideneamino) quinoxaline, internal standard (IS) for quantitation, were provided by Allergan Inc. All other reagents were of special grade or higher and were obtained commercially.
Brimonidine tartrate
Manufactured by Abbvie
Brimonidine tartrate is a medication used in the treatment of certain eye conditions. It is a selective alpha-2 adrenergic agonist that helps to reduce intraocular pressure. The core function of brimonidine tartrate is to lower eye pressure, but its specific intended use should be determined by medical professionals.
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2 protocols using brimonidine tartrate
1
Topical Administration of Brimonidine Tartrate
2
Selective Laser Trabeculoplasty Technique
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All cases of SLT were performed using the same technique, under topical anesthesia by a single experienced glaucoma physician (WK). The Lumenis Selecta Duet (Lumenis, Yokneam, Israel) was used. This is a frequency-doubled, Q-switched, 532 nm, Nd:YAG laser, with a pulse duration of 3 nanoseconds, a spot size of 400 μm, and a pulse energy from 0.4 to 0.8 mJ, coupled to a slit lamp delivery system. Immediately before the laser procedure, a single application of 0.15% brimonidine tartrate (Allergan, Irvine, CA) was instilled into the operative eye to prevent IOP spikes after laser treatment. The patients were postoperatively treated with 1% prednisolone acetate (Allergan, Westport, Ireland) four times a day for 5 days. Patients were examined for 1 hour to monitor IOP spikes (IOP > 30 mm Hg or IOP > 30% from baseline).
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