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Prednisolone acetate

Manufactured by AbbVie
Sourced in United States, Ireland

Prednisolone acetate is a synthetic glucocorticoid medication. It is used as a laboratory reagent and for various research applications.

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11 protocols using Prednisolone acetate

Preoperative management included topical 0.5% levofloxacin eye drops (four times a day; Santen, Japan). Postoperatively, topical steroid (1% prednisolone acetate; Allergan, Irvine, CA, USA) was prescribed for 6 months four times a day. In addition, antibiotic eye drops (0.3% Ofloxacin Eye Ointment; Sinqi; Shenyang, China) was administered four times daily for the 1st month. In addition, 0.1% tacrolimus eye drops (twice 1 day; Senju, Japan) was prescribed particularly for patients who suffered immune-associated corneal ulcer or perforation.
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Preoperative management included topical 0.5% levofloxacin eye drops (four times a day; Santen, Japan). Postoperatively, topical steroid (1% prednisolone acetate; Allergan, Irvine, CA) was prescribed for 6 months four times a day. In addition, anti-biotic eye drops (0.3% Ofloxacin Eye Oitment; Sinqi; Shenyang, China) was administered four times daily during the first month post-op. Corneal crosslinking were suggested to be combined with this procedure to improve the biomechanical strength of the cornea.
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Following the cell injection procedures, all rabbits received a post-operative regime of topical prednisolone acetate 1% (Allergan Inc, NJ, USA) and topical antibiotic tobramycin 1% (Alcon Laboratories) four times a day. An intramuscular injection of 1 mL/kg of dexamethasone sodium phosphate (Norbrook Laboratories, Northern Ireland, UK) was also administered once daily. This medication regime was maintained until the rabbits were sacrificed.
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Following TE-EK or CE-CI, all rabbits received a post-operative regime of topical prednisolone acetate 1% (Allergan Inc, New Jersey, USA) and topical antibiotic tobramycin 1% (Alcon Laboratories) four times a day. An intramuscular injection of 1 mL/kg dexamethasone sodium phosphate (Norbrook Laboratories, Northern Ireland, UK) was also administered once daily. This medication regime was maintained until the rabbits were sacrificed.
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All rabbits received a post-operative regime as previously described52 (link). Briefly, topical prednisolone acetate 1% (Allergan Inc, New Jersey, USA) and topical antibiotic tobramycin 1% (Alcon Laboratories) was applied four times a day. An intramuscular injection of 1 mL/kg dexamethasone sodium phosphate (Norbrook Laboratories, Northern Ireland, UK) was administered once daily. This medication regime was maintained for at least 14 days until the rabbits were sacrificed. All corneal imaging and measurements of intra-ocular pressure (IOP) were performed prior to transplantation, as well as at day 4 and 1, and 2 weeks after surgical procedures. Slit lamp photographs were taken with a Zoom Slit Lamp NS-2D (Righton, Tokyo, Japan) and corneal cross-sectional scans and measurements of corneal thickness were performed using an anterior segment optical coherence tomography system (AS-OCT; Optovue, California, USA). Three measurements were taken for the assessment of central corneal thickness (CCT): at the corneal center (0.0 mm), and at 1 mm either side of the center (+1.0 mm, and −1.0 mm), and the mean value reported. Measurements of IOP were measured using a calibrated tonometer (Tono-pen Avia Vet, Reichert Ophthalmic Instruments, New York, USA).
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Patients will be treated with prednisolone acetate 1% (Allergan, Parsippany-Troy Hills, New Jersey, USA) six times daily in combination with topical antibiotics (tobramycin 0.3%, s.a. ALCON-COUVREUR n.v) and pilocarpine 1% (Bausch & Lomb, Rochester, New York) four times daily for the first 4 weeks after the surgery.
Postoperative follow-up visits will be performed in the paediatric glaucoma clinic at week 1, week 2, week 4, month 3 and then every 3 months (±1 weeks) for 3 years. The scheduled examinations of the follow-up visits are summarised in table 1. Chloral hydrate 10% (0.8 ml/kg, oral or rectal administration, the maximum dose is 10 mL per day) will be applied to patients not compliant for examinations.
If IOP is found to be high at a scheduled visit, topical antiglaucoma medication will be prescribed and the scheduled follow-up interval (if longer than 2 weeks) will be shortened to 2 weeks. Additional surgery will be performed if the IOP is > 21 mm Hg on maximum antiglaucoma medications (including pilocarpine 1%, brinzolamide 1% and latanoprost 0.005%) in two consecutive study visits.
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Following cell-injection procedures, all rabbits received a postoperative regime of topical prednisolone acetate 1% (Allergan Inc, Dublin, Ireland) and topical antibiotic moxifloxacin hydrochloride 0.5% (Vigamox, Alcon Laboratories, Geneva, Switzerland) four times a day. An intramuscular injection of 1 mL/kg dexamethasone sodium phosphate (Norbrook Laboratories, Newry, Northern Ireland, United Kingdom) was also administered once daily. This medication regime was maintained until the rabbits were sacrificed.
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All cases of SLT were performed using the same technique, under topical anesthesia by a single experienced glaucoma physician (WK). The Lumenis Selecta Duet (Lumenis, Yokneam, Israel) was used. This is a frequency-doubled, Q-switched, 532 nm, Nd:YAG laser, with a pulse duration of 3 nanoseconds, a spot size of 400 μm, and a pulse energy from 0.4 to 0.8 mJ, coupled to a slit lamp delivery system. Immediately before the laser procedure, a single application of 0.15% brimonidine tartrate (Allergan, Irvine, CA) was instilled into the operative eye to prevent IOP spikes after laser treatment. The patients were postoperatively treated with 1% prednisolone acetate (Allergan, Westport, Ireland) four times a day for 5 days. Patients were examined for 1 hour to monitor IOP spikes (IOP > 30 mm Hg or IOP > 30% from baseline).
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Following transplantation of the TE-EK graft, all rabbits received a post-operative regime of topical steroid prednisolone acetate (1%; Allergan Inc, Parsippany-Troy Hills, NJ, USA) and topical antibiotic tobramycin (1%; Alcon) for 4 times a day. An intramuscular injection of dexamethasone sodium phosphate (1 mL/kg; Norbrook Laboratories, Newry, Northern Ireland, UK) was also administered once daily. This medication regime was maintained for 28 days.
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The following topical medication regimen was prescribed: levofloxacin eye drops and prednisolone acetate (Allergan, Irvine, CA, USA) eye drops, 4 times/day for 2 weeks; pranoprofen eye drops (Senju Pharmaceutical Ltd., Osaka, Japan), 4 times/day for 1 month. 2 patients were prescribed with Timolol (Wujing, Wuhan, China) for IOP control, 2 times/day for 3 months. Postoperative examinations and data collection were performed as mentioned in previous section.
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