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Analyze Direct 11.0

Manufactured by AnalyzeDirect
Sourced in United States

Analyze Direct 11.0 is a laboratory equipment product. It serves as a core function for data analysis and processing.

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Lab products found in correlation

6 protocols using Analyze Direct 11.0

Placental reactive oxygen intermediates were marked by Analyze Direct 11.0 (AnalyzeDirect, www.analyzedirect.com) software for calculation of the mean signal intensity (SI). For some of the placentas (in which there were fetal movements), the region of interest was manually marked for each scan. The rate of change in contrast material concentration was scaled to the concentration in the vena cava (ROE = rate of enhancement with units of min−1). To quantify the changes in SI dynamics, parameters of initial enhancement and recovery were defined. SI initial enhancement was defined as the ratio between the SI in the first local maximum and the initial SI. SI recovery was defined as the ratio between the SI in the second local maximum and the SI in the local minimum point between the two maximum points (roughly at the middle of the measurement time). Differences in the initial enhancement and recovery parameters in the null placentas from each genotype were compared with the global WT placentas by one‐way ANOVA followed by Tukey's post hoc test.
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We measured volumes on 5-mm thick contiguous slice digital imaging and communications in medicine (DICOM) CT scans using semi-automated computer software (Analyze Direct 11.0, Overland Park, KS) and the pixel intensity threshold technique. We previously demonstrated that CSF volume is a reliable biomarker of brain volume change and more indicative of changes than measuring whole brain volume on CT scans.(28 (link), 34 (link))
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CT is a quick and effective detection tool to confirm the diagnosis of ICH. After admission, all patients underwent head CT examination to confirm the diagnosis. Commercial Analyze Direct 11.0 software (Analyze Direct, Overland Park, MS, USA) was used to determine hematoma volume in CT images. The image analysis is performed by experienced imaging doctors, who are blind to the research object and research plan.
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Kidney volumes were measured on the coronal T2 single-shot fast spin-echo sequence and the coronal T1-3D spoiled gradient echo (Fig. 1). If one of those sequences showed too low quality, the patient was not eligible for these analyses. The assessment of quality was based upon the judgment of one reader whether or not the kidney boundaries were manually traceable. This was predominantly based on the appearance of motion artifacts. When the quality of the image was deemed too low, another reader was asked to confirm this assessment. The kidney boundaries were manually traced using the commercially available software Analyze Direct 11.0 (Analyze Direct, Inc., Overland Park, KS, USA). The kidney volumes were calculated from the set of contiguous images by summing the products of the area measurements within the kidney boundaries and slice thickness. Non-renal parenchyma, e.g., the renal hilus, was excluded from measurement. Importantly, all measurements were performed by readers blinded for patient number and previous TKV measurements.

Examples of the T1-3D spoiled gradient echo (left) and T2 single-shot fast spin echo (right), examples from two different patients on two different scanners

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Upon admission, all patients underwent head CT to confirm the diagnosis of ICH. At the same time, commercial Analyze Direct 11.0 software (Analyze Direct, Overland Park, MS, USA) was used to determine the bleeding volume of ICH. All head CT images are analyzed by experienced imaging doctors who are blinded to the detailed research protocol.
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The baseline NCCT scans were reviewed to determine the presence of associated intraventricular hemorrhage (IVH) and hydrocephalus. Determination of the baseline and follow-up ICH and IVH volumes on NCCT was performed using Analyze Direct 11.0 software. For the identification of Spot Sign presence, CTA images were independently reviewed by two trained readers (AM, MJ). Differences in reader interpretation were adjudicated by consensus agreement, under the supervision of an expert neuroradiologist (JMR). 0.625 or 1.25 mm axial CTA source images were reviewed in “Spot Windows” (width 200, level 110) as previously described (7 (link)). Delayed CTA images were available only for a minority of patients so only first pass CTA acquired images were analyzed. Significant hematoma expansion was defined as as increase in hematoma volume of 6 mL or >30% from the baseline ICH volume on NCCT (9 (link)). The hematoma expansion analysis was performed in the subgroup of subjects that underwent a follow-up NCCT. Illustrative images of CTA spot sign positive pontine hemorrahages are shown in figure 1 and a representative case of CTA spot sign predicting hematoma expansion is shown in figure 2.
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