DMOG-loaded liposomes (DMOG-Lip) were prepared by reverse phase evaporation. In a nutshell, 40 mg of soya phospholipids, 12 mg of cholesterol, and 12 mg of surfactant (DSPE-PEG2000) were dissolved in 5 mL of chloroform solution and added to a round-bottomed flask (Pomex, 5011-100-20). A rotary evaporator at 120 rpm for 3 min was used to remove the organic solvents. After preheating at 50 °C, 5 mL of PBS solution containing 35 mg DMOG was added to the flask. Then, a rotary evaporator at 140 rpm for 5 min was used to hydrate. After 5 min of water bath sonication, the liquid was transferred to a centrifuge tube and sonicated on ice for 30 s with an ultrasonic cell disruptor, repeated three times. Then, it was transferred to an ultrafiltration tube (Merck Millipore, UFC910096) and centrifuged at 4 °C with 18,000×g for 60 min, repeated three times, adding 1–2 mL of PBS at intervals. Finally, the upper liquid in the ultrafiltration tube was the DMOG-loaded liposomes. The obtained liposomes were stored at 4 °C and used up to 1 month after preparation. Transmission electron microscopy (TEM) and Nanoparticle Tracking Analysis (NTA) with a Zetaview (Particle Metrix, Munich, Germany) were performed for the DMOG-loaded liposome size distribution measurement. The DMOG-loaded liposome size was calculated using NTA software (Malvern, Shanghai, China). Dynamic structural changes were identified using Fourier transform infrared spectroscopy (FTIR) on a Nicolet FTIR6700 spectrometer (Thermo Fisher, Massachusetts, USA). The encapsulation rate of the prepared DMOG-Lip was 20.10 % and the drug loading was 10.99 %. Subsequently, the gelatin powder was dissolved in the DMOG-loaded liposomes solution and mixed with P(HEAA-NHS) in the same volume to generate a cohesive hydrogel featuring an even distribution of liposomes. To ensure the consistency of DMOG-Lip concentration for subsequent intervention, the prepared DMOG-Lip solution was diluted by equal volume. Scanning electron microscopy (SEM) was used to characterize the structure of liposomes after loading. The degradation of 10%PHE-Gel@DMOG-Lip was examined with respect to weight loss under 3 mg/mL lysozyme solution at 37 °C within one month by using PBS as the control group. At each time point, the samples were removed from solution and weighed. The weight loss ratio was normalized to the initial weight of the samples. Using the dialysis bag method for liposome release experiments in vitro. In short, placed the liposome in the dialysis bag and clamped both ends of the dialysis bag. Then, put the complex into a 50 ml centrifuge tube filled with PBS (pH = 7.4). Transfer the whole system to the shaker and maintain 37 °C, 80 r·min-1. Sample 1 ml at the scheduled time (30min, 1h, 2h, 4h, 10h, 12h, 1d, 2d, 4d, 7d) for determining the concentration of released DMOG.